The Cancer Genome Interpreter
The Cancer Genome Interpreter (CGI) Platform is designed to identify the tumour alterations that drive cancer or are therapeutically actionable. CGI annotates the tumour variants, identifies oncogenic mutations, and pinpoints biomarkers of drug response. For mutation interpretation, CGI integrates expert knowledge from multiple internal and external databases with data-driven computational methods from its Automatic Learning Platform (comprising IntOGen, BoostDM, RankDM, and RulesDM).
What does the Cancer Genome Interpreter do?
The CGI Platform
The CGI Platform is a comprehensive, clinically oriented software developed as part of the CGI-Clinics project and designed to provide hospitals and researchers with a full suite of functionalities for genomic variants interpretation in cancer. At its core, the CGI Platform incorporates the Interpretation module, which allows users to interpret mutations from a tumor sample.
Beyond this primary function, the CGI Platform includes several integrated modules. These include a data management module, a virtual Molecular Tumor Board (vMTB) module, a Statistics module, and a module for exploring single mutations (My Mutations). These complementary modules significantly enhance the CGI Platform’s utility, streamline data analysis, and facilitate a more complete interpretation of genomic data.
Advanced Genomic Interpretation
Identify oncogenic mutations and biomarkers of drug response by transforming genomic data into actionable insights.
AI-Powered VUS Annotation
Leverage the Automatic Learning Platform and machine learning algorithms to interpret Variants of Uncertain Significance (VUS) with high accuracy.
Cohort Statistics
Generate real-time visualisations and comprehensive statistics from all patient and genomic data to support both decision-making and research.
Virtual Molecular Tumour Boards
Enable international multidisciplinary expert discussion of complex cases through an integrated vMTB module (available in CGI Teams).
Customisable Reporting
Generate professional, editable reports following ESMO guidelines, specifically tailored to your institution’s clinical workflow.
Platform versions
CGI Open
For research use in an academic setting
Available analyses (monthly)
30
Number of Users
1 User
Analysis Storage
60 days
Concurrent Analysis
1
Analysis Priority
No
My Mutations
30
vMTB module
DISABLED
Customisable report
DISABLED
You can register for CGI Open using your institution/university email address.
CGI Teams
For clinical genomics teams, sequencing reports, and hospital-based research
Available analyses (monthly)
5000
Number of Users
Up to 30 users
Analysis Storage
Unlimited
Concurrent Analysis
3
Analysis Priority
Yes
My Mutations
Unlimited
vMTB module
ENABLED
Customisable report
ENABLED
If your hospital already has a license, contact your administrator, who can grant you access to CGI Teams projects. Otherwise, you can request a demo of CGI Teams and information about license terms.
CGI Industry
For teams based in pharma, drug discovery, data services, and commercial products
Available analyses (monthly)
5000
Number of Users
Up to 30 users
Analysis Storage
Unlimited
Concurrent Analysis
3
Analysis Priority
Yes
My Mutations
Unlimited
vMTB module
ENABLED
Customisable report
ENABLED
You can request a demo of CGI Industry and information about license terms.
This resource is intended for research purposes and it must not substitute a doctor’s medical judgement or healthcare professional advice.
People
Scientific Coordination
Núria López-Bigas
Santiago Demajo
Design and Development team
Olivia Tort
Carlos López-Elorduy
Federica Brando
Paula Gomis Rosa
Jordi Deu
Miguel Grau
Magda Guardiola
Contributors
Abel González-Pérez
Joan E. Ramis-Zaldívar
Ferran Muiños
Dafni Chondronasiou
Davide Scarpetta
Izar Villasante
Mònica Sánchez Guixe
Contributing hospitals
The new CGI-Clinics tool has been developed through an iterative feedback process between the technical development team at IRB Barcelona and the ten clinical partners of the CGI-Clinics project.
Developers CGI Platform
The CGI Platform has been developed by IRB Barcelona in collaboration with Eurecat.
